High resolution neurometabolic coupling revealed by focal activation ofvisual neurons.

Citation Info

Thompson, Peterson, Freeman (2004)
High resolution neurometabolic coupling revealed by focal activation ofvisual neurons.
Nature Neuroscience. 7: 919-920

 

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Abstract

Functional magnetic resonance imaging (fMRI) is an important tool for measuring brain function non-invasively, but the vascular and metabolic changes on which its measurements are based are not fully understood. Here, we examined the relationship between these changes and neural activity on a fine spatial scale by use of simultaneous measurements of tissue oxygen and extracellular neural activity within the cat's lateral geniculate nucleus. Our findings indicate that activity-dependent increases in cerebral blood flow and oxidative metabolism occur on different spacial scales and that the ratio between the two depends on the size of the activated neural population